Effects of Jiawei Huangqi Guizhi Decoction on the expression of GAS, MTL, GC, and TGF-β3 signaling pathways in CAG rats

To study the effect of Jiawei Huangqi Guizhi Decoction on gastrointestinal hormones and TGF-β3 signal pathways in rats with chronic atrophic gastritis (CAG). The model was created by methylnitrosoguanidine (MNNG) comprehensive method. After successful modeling, it divided into three groups: group (MC group), frolic acid (AC modified high dose (HH middle (HM low (HL group). Gastric pathology observed HE staining. levels gastrin (GAS) motilin (MTL) rat serum were detected ELISA assay. staining, histopathological sections analyzed. Inflammatory factors infiltration disorder mucosal epithelial cells found group, which improved to some extent after administration. According pathological chart analysis score each compared gastric tissue damage administration has been different degrees, among scores HH HM groups lower, corresponding degree smaller. test results ELISA, could reduce contents GAS, TGF-β3, increase MTL abundance rats, thus accelerating apoptosis tumor inhibiting cancer. played a positive role preventing occurrence cancer through reducing concentrations GAS serum, increasing concentration MLT serum. This provided new treatment idea for CAG.